3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Multiple genome analytics framework: The case of all SARS-CoV-2 complete variantsArticle Published on 2022-11-202022-11-16 Journal: Journal of biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerated Algorithm Algorithms analyses analytics ARPaD bioinformatics Biotechnology can be used center Comparisons Complete computational tool COVID-19 dataset Efficiency framework Genome genome sequence genomic help information introduced knowledge LERP-RSA meta-analyses MPaD MuGA Multiple Multiple genome analytics framework organism palindrome pattern polymerase chain primer problem problems question repeated required resource resources SARS-CoV-2 SARS-CoV-2 genome sequence sequence SPaD. Structure text mining Topic variant variants [DOI] 10.1016/j.jbiotec.2022.09.015 PMC 바로가기
An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunizationArticle Published on 2022-11-052022-11-15 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Antigen antigens applied approach approaches binding affinity circumvent complementary COVID-19 COVID-19 pandemic Delta Diseases evaluated functional fusion strategy generate immunization introduced lack Lipid Lipid nanoparticle (LNP) LNP mAb mAbs Membrane proteins methodology mice Modified mRNA monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity posttranslational modification Prophylactic Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus SARS-CoV-2. serum serum antibody several variants therapeutic drug Treatment Vaccines variants [DOI] 10.1016/j.ijpharm.2022.122256 PMC 바로가기
Antibody responses and SARS-CoV-2 infection after BNT162b2 mRNA booster vaccination among healthcare workers in JapanArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval 95%CI adjusted odds ratio age analyzed anti-spike antibody Antibody Response BNT162b2 BNT162b2 mRNA booster vaccination Booster vaccine Cohort Coverage COVID-19 decrease dose Effectiveness eight Factor group groups HCW HCWs Health care worker healthcare worker Increased infection control interquartile range introduced IQR Japan median mRNA vaccine mRNA vaccine. multivariate logistic regression no significant difference not significant positive risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections subject university vaccination Vaccine waning immunity [DOI] 10.1016/j.jiac.2022.07.010 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
COVID-19 Outbreak Forecasting Based on Vaccine Rates and Tweets ClassificationArticle Published on 2022-10-272022-11-16 Journal: Computational Intelligence and Neuroscience [Category] 치료기술, [키워드] affected Analysis applied caused classification Combination confirmed cases country COVID-19 disease early stage Effectiveness ENhance feature Forecasting glove Health healthcare help IMPROVE infected case introduced machine learning algorithm machine learning model outbreak public health Rate reliability resource spread of COVID-19 Surveillance SVM the disease Vaccine Vaccines virus spread [DOI] 10.1155/2022/4535541 PMC 바로가기
Impact of the New Coronavirus Infection on the Immune System of Children and Adolescents in the Region of the Russian FederationArticle Published on 2022-10-212022-11-15 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 진단, [키워드] absence Active disease Adolescent age analysed analyses Analysis biochemical carried categories caused CD3+CD4+ cellular immunity changes in children Clinical features consequence COVID-19 deviation Diagnosis disease disease stage Epidemiology Federation FIVE flow cytometry group growth Human immune system IgA IgG IgG and IgM IgM Immune status immune system Immunity Immunoglobulin immunograms immunological immunology immunology. immunoregulation Impact Infection interval introduced laboratory diagnosis lack leukocytes Lymphocytes methodology Mutation New New coronavirus NK cell pandemic pathogen Patient patients Perm Krai phagocytic phagocytosis professional public health QR code Quantitative analysis Racial Region Research Russian population SARS-CoV-2 SARS-CoV-2 vaccination selected serological severity System T helper the disease Treatment was performed [DOI] 10.3390/ijerph192013669 PMC 바로가기
Griseofulvin: An Updated Overview of Old and Current KnowledgeArticle Published on 2022-10-182022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] ACE2 addition ascomycetes binding cancer cell capillary blood flow Cell contribute current derivative dermatophytic fungi disrupt domain Drug repurposing ENhance explain FDA-approved drug filament protein griseofulvin griseofulvin derivatives gsf gene cluster Hepatitis hepatitis C virus hepatocyte IMPROVE infections information inhibitory effect Inhibitory effects Interaction introduced K18 Liver injury Mallory mechanism metabolite metabolites mitosis molecular docking analysis multifunctional polyketide compound produced RBD RdRP Replication responsible RNA-dependent RNA polymerase rodent SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease severity Spike protein spindle microtubule. therapeutic interventions treated Vascular viral replication [DOI] 10.3390/molecules27207034 PMC 바로가기
Impact of COVID-19 on the lives and mental health of children and adolescentsArticle Published on 2022-10-182022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adolescent affected age Anxiety children Complete concerning COVID-19 COVID-19 pandemic Digital disease European expand GAD Generalized greater Health help higher education Impact introduced Local lockdown major depressive disorder mental health mental health issue mental health service outcomes pandemic physical distancing Prevalence questionnaire reflected significantly social life. spread of COVID-19 Stress student survey therapeutic union [DOI] 10.3389/fpubh.2022.925213 PMC 바로가기
Deep Transfer Learning for COVID-19 Detection and Lesion Recognition Using Chest CT ImagesArticle Published on 2022-10-152022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition AUC automated can be used caused Chest CT image Chest CT images Chest CT scans CNN Complete Computed tomography coronavirus disease COVID-19 COVID-19 diagnosis CT-scan datasets death deep deep learning detection diagnose Diagnosis Diagnostic method false discovery rate FDR global pandemic heatmap highlight identify Image IMPROVE introduced learning lesion plague radiologist Recognition sensitivity shown specificity starting time-consuming transformer [DOI] 10.1155/2022/4509394 PMC 바로가기